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. 2021 Aug 19;22:604–616. doi: 10.1016/j.omto.2021.08.008

Figure 5.

Figure 5

Target prediction of oridonin

(A) The 3D structure of oridonin was obtained from the PubChem database. (B) GO pathway enrichment analysis of the predicted targets of oridonin was demonstrated by dotplots. (C) The PPI network of tyrosine kinase-related protein networks among the predicted targets of oridonin. (D) Docking poses into the pharmacophore of EGFR tyrosine kinase domain (PDB: -5GNK, in red cartoon representation). Oridonin was represented in gray. (E) The 2-dimensional schematic diagram of interactions of EGFR with oridonin. (F) The pocket view of EGFR binding with oridonin.