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. 2021 Aug 30;24(9):103066. doi: 10.1016/j.isci.2021.103066

Figure 2.

Figure 2

In vivo evaluation of chemogenetic activation of unilateral nigrostriatal dopaminergic (DA) neuron function

(A) A coronal section of parametric image displaying an increase in the standardized uptake value ratio (ΔSUVR) of [18F]fluorodeoxyglucose (FDG) following deschloroclozapine DCZ administration (3 μg/kg intravenous [IV]) overlaying a magnetic resonance image in Marmo4. Red and blue arrowheads indicate the hM3Dq-expressing substantia nigra and its contralateral control side, respectively.

(B) SUVR values of [18F]FDG uptake in the hM3Dq-expressing SN (hM3Dq) and contralateral control SN (control) following agonist and vehicle administration. CNO and DCZ were used as agonist for Marmo3 and 4, respectively. Asterisk indicates a significant difference (p < 0.05, Tukey HSD test).