Table 2.
Source and function of adipokines
| Adipokine | Source | Binding site | Function |
|---|---|---|---|
| Leptin | Adipocytes | Leptin Receptor | Appetite Control, Inflammation |
| Resistin | Adipocytes, Monocytes | Adenylyl Cyclase-Associated Protein 1 (CAP1) | Inflammation, Insulin resistance, atherosclerosis |
| RBP4 | Adipocytes, Macrophages, Liver | Retinol, Transthyretin | Insulin resistance |
| AngpL-2 | Adipocytes | Activates signaling adhesion molecules, monocyte chemotaxis | Inflammation, Insulin resistance |
| IL-6 | Adipocytes, Macrophages | IL-6 Receptor | Pro-inflammatory but variable effects |
| MCP-1 | Adipocytes, Stromal Vascular Cells, Macrophages | CCR2 | Recruits monocytes/macrophages. Causes Inflammation |
| Adiponectin | Adipocytes | Adiponectin Receptors 1 & 2 | Anti-inflammatory, insulin sensitization, anti-atherogenic |
| Omentum-1 | Adipocytes, Stromal Vascular Cells | Triggers AKT activation | Anti-inflammatory, insulin sensitization, anti-atherogenic |