Table 1.
Genetic analysis of TENM4 in SCZ
| FAM_ID | Position | Allele | SNP | AA_Change | AF | No. | Interpro_domain |
|---|---|---|---|---|---|---|---|
| Family_1 | 78,399,126 | A > G | Ns | p.S1745P | ns | 7 | YD repeats |
| Family_2 | 78,369,210 | G > C | rs527857070 | p.Q2735E | 1.605 × 10−5 | 6 | Tox-GHH domain |
| 78,443,605 | T > C | rs141471364 | p.N965S | 0.0053 | 3 | Carboxypeptidase-like, regulatory domain | |
| Family_3 | 78,574,076 | C > T | rs3812723 | p.V396I | 0.0003 | 3 | . |
| Family_4 | 78,383,326 | T > C | rs772977333 | p.T1849A | 0.0002 | 9 | YD repeats |
SNP, single-nucleotide polymorphism; AA, amino acid; AF, allele frequency; No. the number of software that supported the damaging effect of the missense mutation on TENM4 protein function.