REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal anti-β-Tubulin	Abcam	Cat#ab6046; RRID:AB_10807712
Rabbit polyclonal anti-SREBP2	Abcam	Cat#30682; RRID:AB_779079
Rabbit monoclonal anti-phospho-Akt Serine 473 (D9E)	Cell Signaling	Cat#4060; RRID:AB_2315049
Rabbit polyclonal anti-Akt	Cell Signaling	Cat#9272; RRID:AB_329827
Rabbit monoclonal anti-phospho-AMPKα Threonine 172 (40H9)	Cell Signaling	Cat#2535; RRID:AB_331250
Rabbit polyclonal anti-AMPKα	Cell Signaling	Cat#2532; RRID:AB_330331
Rabbit polyclonal anti-phospho-GSK3B Serine 9	Cell Signaling	Cat#9336; RRID:AB_331405
Mouse monoclonal Anti-TAF15	EnCor Biotechnology	Cat#MCA-4D71; RRID:AB_2572388
Mouse monoclonal anti-CYP7A1 (15B9.1)	Millipore	Cat#MABD42; RRID:AB_2756360
Rabbit polyclonal anti-Gli1	Novus Biologicals	Cat#NB600-600; RRID:AB_2111758
Rabbit polyclonal anti-HMGCR (JF0981)	Novus Biologicals	Cat#NBP2-66888; RRID:AB_2860021
Rabbit polyclonal anti-SRB1	Novus Biologicals	Cat#NB400-101; RRID:AB_10107658
Rabbit polyclonal anti-AACS	Proteintech	Cat#13815-1-AP; RRID:AB_2877977
Rabbit polyclonal anti-ACAT2	Proteintech	Cat#14755-1-AP; RRID:AB_2220236
Mouse monoclonal anti-β-Actin HRP (C4)	Santa Cruz	Cat#sc-47778; RRID:AB_2714189
Rabbit polyclonal anti-EGFR (1005)	Santa Cruz	Cat#sc-03; RRID:AB_631420
Mouse monoclonal anti-FGF-15 (D-9)	Santa Cruz	Cat#sc-514647
Mouse monoclonal anti-FXR/NR1H4 (D-3)	Santa Cruz	Cat#sc-25309; RRID:AB_628039
Rabbit polyclonal anti-Gli2 (H-300)	Santa Cruz	Cat#sc-28674; RRID:AB_2111908
Rabbit polyclonal anti-Gli3 (H-280)	Santa Cruz	Cat#sc-20688; RRID:AB_2109708
Mouse monoclonal anti-SHP (H-5)	Santa Cruz	Cat#sc-271511; RRID:AB_10649803
Mouse monoclonal anti-SREBP-1 (2A4)	Santa Cruz	Cat#sc-13551; RRID:AB_628282
Rabbit polyclonal anti-APOC2	Thermo Fisher	Cat#PA5-102480; RRID:AB_2851882
Rabbit polyclonal anti-APOC3	Thermo Fisher	Cat#PA5-116572
Rabbit polyclonal anti-CYP8B1	Thermo Fisher	Cat#PA5-37088; RRID:AB_2553905
Anti-mouse IgG, HRP-linked antibody	Cell Signaling	Cat#7076; RRID:AB_330924
Rabbit IgG HRP Linked Whole antibody	Millipore	Cat#GENA934-1ML; RRID:AB_2722659
Bacterial and virus strains
AAV.TBG.Pl.Cre.rBG	James M. Wilson Lab, Penn Vector Core	Addgene AAV8; 107787-AAV8
pENN.AAV.TBG.Pl.ffLuciferase.RBG	James M. Wilson Lab, Penn Vector Core	Addgene, AAV8; 105538-AAV8
Chemicals, peptides, and recombinant proteins
Blotting-Grade Blocker	BIO-RAD	Cat# 1706404
Clarity Western ECL Substrate	BIO-RAD	Cat# 1705060
Bovine Serum Albumin ≥98%	Millipore Sigma	Cat# A7906-500G
Chloroform	Millipore Sigma	Cat# CX1060-1
cOmplete Mini EDTA-free Protease Inhibitor Cocktail	Millipore Sigma	Cat# 4693159001
Oil Red O	Millipore Sigma	Cat# O0625-25G
RIPA Buffer	Millipore Sigma	Cat# R0278-500ML
Restore Western Blot Stripping Buffer	Thermo Fisher	Cat# 21063
TRIzol Reagent	Thermo Fisher	Cat# 15596018
Critical commercial assays
Cholesterol/Cholesteryl Ester Quantitation Assay Kit	Abcam	Cat# ab65359
Triglyceride Colorimetric Assay Kit	Cayman Chemical	Cat# 10010303
Mouse Total Bile Acids Assay Kit	Crystal Chem	Cat# 80470
High-Capacity cDNA Reverse Transcription Kit	Thermo Fisher	Cat# 4368814
Pierce BCA Protein Assay Kit	Thermo Fisher	Cat# 23225
PowerTrack SYBR Green Master Mix	Thermo Fisher	Cat# A46111
Deposited data
Raw and analyzed data from this paper	This Paper	Mendeley Data; https://doi.org/10.17632/6mcj5n2xwg.1
Experimental models: Organisms/strains
Mouse Smotm2Amc/J (SMO-flox)	Jackson Laboratory	JAX stock# 004526
Oligonucleotides
Primers for Mus Musculus, see Table S1	This Paper	N/A
Software and algorithms
GraphPad Prism Version 5 for Windows	GraphPad Software	https://www.graphpad.com
Primer-Blast	NIH	https://www.ncbi.nlm.nih.gov/tools/primer-blast/index.cgi?LINK_LOC=BlastHome
ImageJ Software	NIH	https://imagej.nih.gov/ij/
Microsoft Excel	Microsoft Corporation	https://office.microsoft.com/excel
Other
5053 - PicoLab Rodent Diet 20 (Chow Diet)	LabDiet	Cat# 3005740-220
Standard chow diet (0.02% w/w cholesterol)	Envigo	Cat# 130104
High cholesterol diet (0.2% w/w cholesterol)	Envigo	Cat# 160514
Kinetex 2.6 μm C18 LC column 150 x 4.6 mm	Phenomenex	Cat# 00F-4462-E0
ChemiDoc MP Imaging System	BIO-RAD	Cat# 17001402
Nitrocellulose Membrane	BIO-RAD	Cat# 1620112
StepOnePlus Real-Time PCR System	Applied Biosystems	Cat# 4376600
Tecan Infinite M200 Pro Microplate Reader	Tecan	Model# M200