Figure 4.

Impact of phenotypic persistence for directed migration

(A) Increasing migrational bias (b^∗ = 0.5) without phenotypic persistence (T_p = 0) does not drive invasion of GFP+ cells outside the tumor.

(B) Under intermediate phenotypic persistence (T_p = 50 hr), GFP+ invasive “plumes” form inside the normoxic DsRed+ zones. Some GFPp + cells escape to invade the surrounding tissue.

(C) Escape of GFP+ cells increases under permanent phenotypic persistence (T_p = ∞).

(D) For transient phenotypic persistence (T_p = 50 hr) and intermediate migrational bias (b^∗ = 0.5), decreasing the number of “responder” cells to 50%, 10%, and 1% gradually inhibits the formation of invasive plumes, although GFP+ cells continue to escape the tumor.