Figure 6.

CCR7-mediated cDC1 relocalization into the T cell zone promotes MCMV-specific CD8+ T cell responses and host resistance to MCMV infection

(A) Analysis of m45-specific CD8⁺ T cell response in Xcr1^−/− mice and littermate controls 6 days after MCMV infection. One representative experiment of two independent ones with at least 4 mice per group is shown. ∗, p < 0.05.

(B) Analysis of m45-specific CD8⁺ T cell response in Wt:Xcr1-Dta, Wt:Ccr7^−/− and Xcr1-Dta:Ccr7^−/− BM chimera mice 6 days after MCMV infection (10⁴ PFU). Two independent experiments with at least 4 mice per infected group were pooled. A one-way ANOVA statistical analysis with a Tukey's multiple comparison test was applied. ∗∗, p < 0.01; ∗, p < 0.05, n.s., nonsignificant. Statistical analysis between all other groups is nonsignificant.

(C) MCMV titers in spleens and livers of Wt and Xcr1^−/− mice 5 days after MCMV infection (10⁴ PFU). Two independent experiments with at least 3 mice per infected group were pooled. NI, noninfected. ∗∗∗, p < 0.001.

See also Figure S6.