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Five most frequent VH and VL germlines in 77 marketed antibody-based biotherapeutics
| VH germline | No. | VL germline | No. | No. of germline pairs |
| IGHV1-46*01 | 15 | IGKV1-39*01 | 11 | 5 |
| IGHV1-46*01 | 15 | IGKV3-11*01 | 11 | 3 |
| IGHV3-23*04 | 5 | IGKV1-NL1*01 | 5 | 3 |
| IGHV3-7*01 | 3 | IGKV3-20*01 | 6 | 2 |
| IGHV1-3*01 | 4 | IGKV1-33*01 | 9 | 2 |
