Table 4.

Average values and ranges for five nonredundant descriptors and Z-distances for the Fv regions of 77 marketed antibody-based biotherapeutics, 271 CST, 14,037 human, and 3,120 internal hit antibodies

Descriptor	79 Fvs in 77 marketed biotherapeutics*	271 CST antibodies	14,037 human antibodies	3,120 internal hits
BSA_VL: VH (Å2)	797 ± 81 (618 to 1,046)	781 ± 93 (585 to 1,211)	796 ± 83 (436 to 1,456)	778 ± 82 (521 to 1,318)
pIFv_3D	7.9 ± 1.2 (4.3 to 9.5)	7.7 ± 1.3 (4.6 to 9.9)	8 ± 1.3 (4.1 to 10.3)	7.8 ± 1.3 (3.9 to 9.8)
RM(µD/µH) (D)	1.1 ± 0.6 (0.1 to 3.6)	1.07 ± 0.7 (0.1 to 6.1)	0.9 ± 0.8 (0 to 22.9)	1.08 ± 1.07 (0.1 to 42.3)
RP	1.8 ± 0.5 (1.0 to 3.3)	2 ± 0.9 (0.6 to 11.1)	1.9 ± 0.9 (0.3 to 16)	1.7 ± 0.7 (0.4 to 7.8)
Avg_HI	1 ± 0.4 (0.3 to 1.9)	0.9 ± 0.4 (0.14 to 2.3)	1 ± 0.4 (0 to 3.1)	0.9 ± 0.4 (0.03 to 3.2)
Z-distance	2.1 ± 0.7 (0.6 to 4.2)	2.5 ± 1.4 (0.7 to 18.6)	2.5 ± 1.4 (0.3 to 37.5)	2.4 ± 1.7 (0.5 to 71.5)

^*Note that the ranges for the five nonredundant descriptors are smaller for the Fvs from marketed biotherapeutics.