Fig. 2.

PCA of 33 AD or 6 selected dementia-related compounds showed significant differences between patients with dementia and HE subjects. Blood data of dementia and HE subjects were subjected to PCA. (A) A PCA plot using abundances of 33 (7 increased and 26 decreased) dementia-related compounds. Dementia and HE subjects were separated into two domains (see text). Red, dementia; green, HE. (B) PCA was also performed using only 6 selected dementia markers (dimethyl-guanosine, pseudouridine, S-methyl-ET, ET, trimethyl-histidine, and NADP⁺).