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. 2021 Sep 18;22:248. doi: 10.1186/s12931-021-01840-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Circ_PIP5K1A interacted with miR-493-5p. A the binding sites between circ_PIP5K1A and miR-493-5p were exhibited by starbase. B, C dual-luciferase reporter assay was used to validate the binding between circ_PIP5K1A and miR-493-5p in A549/DDP (B) and H460/DDP (C) cells. D RT-qPCR was applied for the expression detection of miR-493-5p after transfection of si-NC or si-circ_PIP5K1A. E, F the level of miR-493-5p was analyzed using RT-qPCR in DDP-resistant cells (E) and tumor-resistant tissues (F). G Pearson’s correlation coefficient was applied for the analysis of relationship between miR-493-5p and circ_PIP5K1A in tumor-resistant tissues. ***P < 0.001