Table 2.
hepatitis B, C and D outcomes for selected subsets from the EMINI paediatric cohort (2009)
| Paediatric cohort | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age groups (years) | 0 to <6 | 6 to <8 | 8 to <15 | 15 to <19 | ||||||||
| Overall N=36 | HIV+ N=13 | HIV- N=23 | Overall N=60 | HIV+ N=12 | HIV- N=48 | Overall N=58 | HIV+ N=23 | HIV- N=35 | Overall N=60 | HIV+ N=14 | HIV- N=46 | |
| Male gender | 17/36 (47.2%) | 6/13 (46.2%) | 11/23 (47.8%) | 33/60 (55.0%) | 6/12 (50.0%) | 27/48 (56.3%) | 26/58 (44.8%) | 9/23 (39.1%) | 17/35 (48.6%) | 27/60 (45.0%) | 4/14 (28.6%) | 23/46 (50.0%) |
| HBsAg+ | 3/36 (8.3%) | 3/13 (23.1%) | 0/23 (0.0%) | 8/60 (13.3%) | 2/12 (16.7%) | 6/48 (12.5%) | 10/58 (17.2) | 4/23 (17.4%) | 6/35 (17.1%) | 8/60 (13.3) | 2/14 (14.3%) | 6/46 (13.0%) |
| HBeAg+ | 2/3 (66.7%) | 2/3 (66.7%) | 0/0 | *0/7 (0.0%) | 0/2 (0.0%) | *0/5 (0.0%) | 4/10 (40.0%) | 2/4 (50.0%) | 2/6 (33.3%) | *2/3 (66.7%) | *1/1 (100.0%) | *1/2 (50.0%) |
| Anti-HBe+ | 0/3 (0.0%) | 0/3 (0.0%) | 0/0 | *1/7 (14.3%) | 0/2 (0.0%) | *1/5 (20.0%) | 3/10 (30.0%) | 1/4 (25.0%) | 2/6 (33.3%) | 0/3 (0.0%) | *0/1 (0.0%) | *0/2 (0.0%) |
| Anti-HBs+ only | 15/36 (41.7%) | 1/13 (7.7%) | 14/23 (60.9%) | 14/60 (23.3%) | 1/12 (8.3%) | 13/48 (27.1%) | 2/58 (3.5%) | 2/23 (8.7%) | 0/35 (0.0%) | 0/60 (0.0%) | 0/14 (0.0%) | 0/46 (0.0%) |
| Anti-HBc+ total | 1/36 (2.8) | 0/13 (0.0%) | 1/23 (4.4%) | 0/60 (0.0%) | 0/12 (0.0%) | 0/48 (0.0%) | 5/58 (8.6%) | 1/23 (4.4%) | 4/35 (11.4%) | 7/60 (11.7%) | 2/14 (14.3%) | 5/46 (10.9%) |
| HBV naive | 17/36 (47.2%) | 9/13 (69.2%) | 8/23 (34.8%) | 38/60 (63.3%) | 9/12 (75.0%) | 29/48 (60.4%) | 41/58 (70.7%) | 16/23 (69.6%) | 25/35 (71.4%) | 45/60 (75.0%) | 10/14 (71.4%) | 35/46 (76.1%) |
| HCV+ | 0/36 (0.0%) | 0/60 (0.0%) | 4/58 (6.9%) | 3/60 (5.0%) | ||||||||
| HDV+ | 0/3 (0.0%) | 0/8 (0.0%) | 2/10 (20.0%) | 0/8 (0.0%) | ||||||||
Data is indicated in numbers (%); HBsAg=hepatitis B surface antigen; HBeAg=hepatitis B e antigen; anti-HBe=hepatitis B e antibodies; HBV=hepatitis B; HCV=hepatitis C; HDV=hepatitis delta antigen, note: the proportions between HIV+ and HIV- do not correspond to HIV prevalence for both paediatric and adult cohorts, as samples were selected purposively by HIV status, the proportions between HBsAg+ and HBsAg- do not correspond to prevalence of HBsAg, as adult samples were selected purposively by HBsAg status, especially in the paediatric group sample volumes were limited, so that not all serological analyses could be performed; * are indicating the denominators that are smaller than in the overall group