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. 2021 Jun 30;26(10):1977–1985. doi: 10.1007/s10147-021-01973-1

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© The Author(s) 2021

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Fig. 1 — Study design. MTD was defined as the maximal dose level at which the incidence of dose-limiting toxicity did not exceed 33%. MTD maximum tolerated dose, PLD pegylated liposomal doxorubicin