Table 3.

Pharmacokinetic parameters

Parameter	Trabectedin		Doxorubicin
	Level 1 (n = 6)	Level 2 (n = 12)	Level 1 (n = 6)	Level 2 (n = 12)
tmax, h	2.68 ± 0.94	2.78 ± 0.66	4.38 ± 1.70	4.37 ± 1.80
Cmax, *pg/mL or **µg/mL	8640 ± 1320*	9890 ± 3150*	19.8 ± 1.7**	22.2 ± 3.0**
AUC0–inf, *ng·h/mL or **µg·h/mL	61.5 ± 7.4*	83.7 ± 69.0*	2542.0 ± 391.2**	1941.2 ± 548.3**
t½, h	102.8 ± 27.8	124.9 ± 100.2	92.0 ± 15.3	61.0 ± 12.7
CL, *L/h or **mL/h	21.5 ± 2.2*	26.8 ± 9.3*	17.7 ± 3.4**	26.9 ± 9.1**
Vdss, L	1461 ± 456	1921 ± 727	2.26 ± 0.27	2.15 ± 0.35

All data are expressed as mean ± SD

AUC_0–inf area under the concentration–time curve from zero to infinity, CL clearance, C_max maximum concentration, SD standard deviation, t_½ terminal half-life, t_max time to C_max, Vd_ss volume of distribution at steady state