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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Neurosci Res. 2021 May 21;172:99–109. doi: 10.1016/j.neures.2021.05.007

Figure 7. Metformin significantly activates Par1 in primary cortical neurons.

Figure 7.

Primary neuronal cultures were treated with 1mM of vehicle or metformin for 2 hours. Protein lysates were probed for Par1, phospho-Par1 (p-Par1) and GAPDH as a loading control. Par1 was significantly activated following metformin treatment as determined by a significant increase in the p-Par1/Par1 ratio. Data represent the mean ±SEM. A 1-way ANOVA was performed with Tukey’s post-hoc test, **p<0.01.