. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: Magn Reson Imaging. 2021 Jul 3;83:1–13. doi: 10.1016/j.mri.2021.06.022

Table 2.

Diffusion metric estimates (mean ± standard error of the mean (SE)) in each brain region of interest for the 8 months old mice. For group comparison, a two-tailed, two-sample t-test with significance at the level of p≤ 0.05 (in bold) after Benjamini-Hochberg false discovery rate was applied to correct for multiple comparisons (8 dMRI metrics compared within each ROI). Mean diffusivity (MD); axial diffusivity (D_∥); radial diffusivity (D_⊥); fraction anisotropy (FA); mean kurtosis (MK); axial kurtosis (K_∥); radial kurtosis (K_⊥); kurtosis fraction anisotropy (KFA); normal control (NC) and 3xTG-AD (TG) groups; basal forebrain (BF), hippocampus (HP), fimbria (Fi) and fornix (Fx).

	MD μm²/ms	D_∥ μm²/ms	D_⊥ μm²/ms	FA	MK	K_∥	K_⊥	KFA

BF
NC	0.81 ± 0.005	1.12 ± 0.011	0.65 ± 0.004	0.34 ± 0.005	1.04 ± 0.010	1.00 ± 0.007	1.10 ± 0.020	0.46 ± 0.008
TG	0.81 ± 0.005	1.09 ± 0.008	0.67 ± 0.004	0.31 ± 0.004	1.05 ± 0.011	0.99 ± 0.010	1.12 ± 0.013	0.42 ± 0.006
P-values	0.542	0.042	0.004	0.0002	0.542	0.542	0.542	0.0007
Cohen’s d	0.189	−0.73	1.05	−1.44	0.22	−0.23	0.25	−1.26
HP
NC	0.79 ± 0.004	0.88 ± 0.005	0.74 ± 0.004	0.13 ± 0.002	0.77 ± 0.008	0.77 ± 0.007	0.78 ± 0.009	0.33 ± 0.006
TG	0.81 ± 0.003	0.92 ± 0.004	0.75 ± 0.003	0.14 ± 0.001	0.78 ± 0.005	0.77 ± 0.005	0.80 ± 0.006	0.32 ± 0.004
P-values	0.0002	<.0001	0.006	0.0002	0.182	0.806	0.034	0.117
Cohen’s d	1.00	1.83	0.97	1.41	0.44	0.07	0.73	−0.54
Fi
NC	1.02 ± 0.011	1.84 ± 0.012	0.61 ± 0.012	0.60 ± 0.006	1.15 ± 0.012	0.75 ± 0.004	1.91 ± 0.034	0.58 ± 0.008
TG	1.05 ± 0.007	1.85 ± 0.012	0.65 ± 0.007	0.58 ± 0.004	1.13 ± 0.008	0.75 ± 0.005	1.81 ± 0.021	0.54 ± 0.005
P-values	0.028	0.807	0.003	0.001	0.442	0.615	0.014	0.001
Cohen’s d	0.76	0.07	1.05	−1.19	−0.30	−0.19	−0.87	−1.26
Fx
NC	0.90 ± 0.008	1.46 ± 0.013	0.61 ± 0.013	0.51 ± 0.009	1.07 ± 0.011	0.83 ± 0.014	1.45 ± 0.021	0.53 ± 0.011
TG	0.92 ± 0.007	1.48 ± 0.011	0.65 ± 0.009	0.48 ± 0.007	1.09 ± 0.009	0.85 ± 0.008	1.47 ± 0.015	0.50 ± 0.008
P-values	0.053	0.423	0.053	0.132	0.132	0.423	0.423	0.053
Cohen’s d	0.81	0.27	0.75	−0.56	0.54	0.29	0.25	−0.74