. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: Magn Reson Imaging. 2021 Jul 3;83:1–13. doi: 10.1016/j.mri.2021.06.022

Table 3.

Diffusion metric estimates (mean ± standard error of the mean (SD)) in each brain region of interest for the 8 months old mice. For group comparison, a two-tailed, two-sample t-test with significance at the level of p≤ 0.05 (in bold) after Benjamini-Hochberg false discovery rate was applied to correct for multiple comparisons (8 dMRI metrics compared within each ROI). Mean diffusivity (MD); axial diffusivity (D_∥); radial diffusivity (D_⊥); fraction anisotropy (FA); mean kurtosis (MK); axial kurtosis (K_∥); radial kurtosis (K_⊥); kurtosis fraction anisotropy (KFA); normal control (NC) and 3xTG-AD (TG) groups; basal forebrain (BF), hippocampus (HP), fimbria (Fi) and fornix (Fx).

	MD μm²/ms	D_∥ μm²/ms	D_⊥ μm²/ms	FA	MK	K_∥	K_⊥	KFA

BF
NC	0.80 ± 0.011	1.09 ± 0.014	0.65 ± 0.011	0.32 ± 0.009	1.09 ± 0.018	1.02 ± 0.012	1.17 ± 0.022	0.43 ± 0.012
TG	0.80 ± 0.010	1.07 ± 0.012	0.66 ± 0.011	0.31 ± 0.005	1.05 ± 0.028	0.99 ± 0.016	1.13 ± 0.037	0.41 ± 0.016
P-values	0.849	0.502	0.502	0.426	0.502	0.426	0.502	0.555
Cohen’s d	0.08	−0.48	0.40	−0.75	−0.52	−0.79	−.040	−0.31
HP
NC	0.79 ± 0.013	0.90 ± 0.013	0.74 ± 0.013	0.13 ± 0.004	0.79 ± 0.011	0.82 ± 0.015	0.80 ± 0.011	0.35 ± 0.023
TG	0.79 ± 0.005	0.90 ± 0.006	0.73 ± 0.005	0.14 ± 0.003	0.78 ± 0.017	0.79 ± 0.014	0.80 ± 0.020	0.34 ± 0.012
P-values	0.959	0.959	0.959	0.959	0.959	0.856	0.959	0.959
Cohen’s d	−0.07	0.14	−0.19	0.43	−0.22	−0.75	0.02	−0.15
Fi
NC	1.01 ± 0.016	1.81 ± 0.029	0.62 ± 0.018	0.59 ± 0.012	1.15 ± 0.023	0.76 ± 0.012	1.88 ± 0.078	0.56 ± 0.011
TG	0.99 ± 0.016	1.78 ± 0.016	0.59 ± 0.017	0.58 ± 0.008	1.19 ± 0.014	0.78 ± 0.009	1.94 ± 0.040	0.57 ± 0.012
P-values	0.529	0.529	0.529	0.529	0.529	0.529	0.529	0.695
Cohen’s d	−0.46	−0.38	−0.40	0.35	0.65	0.50	0.33	0.17
Fx
NC	0.89 ± 0.013	1.46 ± 0.019	0.60 ± 0.016	0.51 ± 0.013	1.11 ± 0.025	0.85 ± 0.023	1.52 ± 0.040	0.53 ± 0.012
TG	0.88 ± 0.014	1.41 ± 0.017	0.61 ± 0.016	0.49 ± 0.011	1.15 ± 0.017	0.89 ± 0.012	1.54 ± 0.036	0.51 ± 0.013
P-values	0.695	0.328	0.695	0.422	0.422	0.328	0.695	0.525
Cohen’s d	−0.23	−0.85	0.17	−0.57	0.61	0.81	0.19	−0.44