Table 4.
Diffusion tensor (DT) and diffusional kurtosis (DK) metrics slope estimates in each brain region for the period of 2 to 8 months of age. Normal control (NC) and 3xTG-AD (TG) groups; S: slope estimates; SE: standard error of the slope; mean diffusivity (MD); axial diffusivity (D∥); radial diffusivity (D⊥); fraction anisotropy (FA); mean kurtosis (MK); axial kurtosis (K∥); radial kurtosis (K⊥); kurtosis fraction anisotropy (KFA); p-values at the level of p≤ 0.05 (in bold) after Benjamini-Hochberg false discovery rate applied to correct for multiple comparisons (8 dMRI metrics compared within each ROI).
| BF | S | SE | P-values | S | SE | P-values | |
|
| |||||||
| MD μm2/ms | MK | ||||||
| Slope NC | −0.00211 | 0.001258 | 0.1964 | Slope NC | 0.003877 | 0.002703 | 0.2504 |
| Slope TG | 0.000421 | 0.000982 | 0.6694 | Slope TG | 0.01079 | 0.002109 | <.0001 |
| D∥ μm2/ms | K ∥ | ||||||
| Slope NC | −0.00704 | 0.002022 | 0.0037 | Slope NC | 0.006126 | 0.002518 | 0.0477 |
| Slope TG | −0.00432 | 0.001578 | 0.0092 | Slope TG | 0.008235 | 0.001965 | 0.0002 |
| D⊥ μm2/ms | K ⊥ | ||||||
| Slope NC | 0.000239 | 0.001117 | 0.8312 | Slope NC | −0.00412 | 0.0042 | 0.4306 |
| Slope TG | 0.002708 | 0.000871 | 0.0038 | Slope TG | 0.01179 | 0.003279 | 0.001 |
| FA | KFA | ||||||
| Slope NC | −0.00307 | 0.000836 | 0.0031 | Slope NC | −0.00153 | 0.001679 | 0.4192 |
| Slope TG | −0.00369 | 0.000654 | <.0001 | Slope TG | −0.00524 | 0.00131 | 0.0003 |
|
| |||||||
| HP | S | SE | P-values | S | SE | P-values | |
|
| |||||||
| MD μm2/ms | MK | ||||||
| Slope NC | −0.00058 | 0.001055 | 0.8529 | Slope NC | −0.0005 | 0.001601 | 0.8661 |
| Slope TG | 0.000612 | 0.000824 | 0.6138 | Slope TG | 0.002793 | 0.001249 | 0.1013 |
| D∥ μm2/ms | K ∥ | ||||||
| Slope NC | 0.000206 | 0.001459 | 0.8881 | Slope NC | −0.00063 | 0.001651 | 0.8661 |
| Slope TG | 0.001786 | 0.001141 | 0.1944 | Slope TG | 0.00186 | 0.001289 | 0.3077 |
| D⊥ μm2/ms | K ⊥ | ||||||
| Slope NC | −0.00098 | 0.000892 | 0.7329 | Slope NC | −0.00069 | 0.001798 | 0.8661 |
| Slope TG | −4.83E-6 | 0.000697 | 0.9945 | Slope TG | 0.002975 | 0.001403 | 0.1013 |
| FA | KFA | ||||||
| Slope NC | 0.000938 | 0.000521 | 0.5666 | Slope NC | 0.002045 | 0.000978 | 0.1931 |
| Slope TG | 0.001325 | 0.000407 | 0.0145 | Slope TG | 0.000143 | 0.000763 | 0.9732 |
|
| |||||||
| Fi | S | SE | P-values | S | SE | P-values | |
|
| |||||||
| MD μm2/ms | MK | ||||||
| Slope NC | 0.008025 | 0.001772 | <.0001 | Slope NC | 0.006069 | 0.001857 | 0.0028 |
| Slope TG | 0.00666 | 0.001383 | <.0001 | Slope TG | 0.005122 | 0.00145 | 0.0013 |
| D∥ μm2/ms | K ∥ | ||||||
| Slope NC | 0.01672 | 0.002665 | <.0001 | Slope NC | −0.0057 | 0.001044 | <.0001 |
| Slope TG | 0.01554 | 0.00208 | <.0001 | Slope TG | −0.00674 | 0.000815 | <.0001 |
| D⊥ μm2/ms | K ⊥ | ||||||
| Slope NC | 0.003672 | 0.001727 | 0.0428 | Slope NC | 0.02136 | 0.005481 | 0.0005 |
| Slope TG | 0.002351 | 0.00135 | 0.0867 | Slope TG | 0.01676 | 0.00428 | 0.0005 |
| FA | KFA | ||||||
| Slope NC | 0.001382 | 0.001065 | 0.1992 | Slope NC | −0.00351 | 0.001271 | 0.01 |
| Slope TG | 0.001638 | 0.000831 | 0.0609 | Slope TG | −0.00333 | 0.000993 | 0.0018 |
|
| |||||||
| Fx | S | SE | P-values | S | SE | P-values | |
|
| |||||||
| MD μm2/ms | MK | ||||||
| Slope NC | −0.00943 | 0.002231 | 0.0002 | Slope NC | 0.000249 | 0.002831 | 0.9721 |
| Slope TG | −0.00492 | 0.001741 | 0.0085 | Slope TG | 0.009508 | 0.00221 | 0.0002 |
| D∥ μm2/ms | K ∥ | ||||||
| Slope NC | −0.00019 | 0.002489 | 0.9382 | Slope NC | 0.000375 | 0.002168 | 0.9721 |
| Slope TG | 0.003209 | 0.001943 | 0.1036 | Slope TG | 0.004499 | 0.001693 | 0.0114 |
| D⊥ μm2/ms | K ⊥ | ||||||
| Slope NC | −0.01418 | 0.002801 | <.0001 | Slope NC | 0.009921 | 0.004312 | 0.0396 |
| Slope TG | −0.00919 | 0.002187 | 0.0002 | Slope TG | 0.02239 | 0.003365 | <.0001 |
| FA | KFA | ||||||
| Slope NC | 0.009179 | 0.001603 | <.0001 | Slope NC | 0.01148 | 0.002441 | <.0001 |
| Slope TG | 0.007258 | 0.001253 | <.0001 | Slope TG | 0.006112 | 0.001905 | 0.0034 |