. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: Magn Reson Imaging. 2021 Jul 3;83:1–13. doi: 10.1016/j.mri.2021.06.022

Table 5.

Diffusion tensor (DT) and diffusional kurtosis (DK) metrics slope estimates in each brain region for the period of 2 to 8 months of age. Normal control (NC) and 3xTG-AD (TG) groups; S: slope estimates; SE: standard error of the slope; mean diffusivity (MD); axial diffusivity (D_∥); radial diffusivity (D_⊥); fraction anisotropy (FA); mean kurtosis (MK); axial kurtosis (K_∥); radial kurtosis (K_⊥); kurtosis fraction anisotropy (KFA); p-values at the level of p≤ 0.05 (in bold) after Benjamini-Hochberg false discovery rate applied to correct for multiple comparisons (8 dMRI metrics compared within each ROI).

BF	S	SE	P-values		S	SE	P-values

MD μm²/ms				MK
Slope NC	−0.0014	0.001458	0.3881	Slope NC	0.008032	0.003201	0.059
Slope TG	−0.00166	0.001219	0.7148	Slope TG	0.00075	0.002681	0.892
D_∥ μm²/ms				K _∥
Slope NC	−0.00513	0.002344	0.0672	Slope NC	0.003224	0.002993	0.3684
Slope TG	−0.00356	0.001961	0.5959	Slope TG	−0.00022	0.002507	0.9295
D_⊥ μm²/ms				K _⊥
Slope NC	0.000546	0.001328	0.6825	Slope NC	0.01051	0.004836	0.0672
Slope TG	−0.00063	0.001112	0.892	Slope TG	0.001296	0.004039	0.8561
FA				KFA
Slope NC	−0.00291	0.001032	0.0519	Slope NC	−0.00416	0.002015	0.0672
Slope TG	−0.0007	0.000865	0.892	Slope TG	−0.00062	0.001689	0.892

HP	S	SE	P-values		S	SE	P-values

MD μm²/ms				MK
Slope NC	0.000842	0.001435	0.6386	Slope NC	0.003739	0.001911	0.1465
Slope TG	−0.00267	0.001228	0.1145	Slope TG	0.000606	0.001601	0.7063
D_∥ μm²/ms				K _∥
Slope NC	0.001718	0.001494	0.5071	Slope NC	0.006666	0.001965	0.0097
Slope TG	−0.00294	0.001275	0.1145	Slope TG	0.001657	0.001646	0.5086
D_⊥ μm²/ms				K _⊥
Slope NC	0.000413	0.001431	0.7734	Slope NC	0.002172	0.002148	0.4357
Slope TG	−0.00252	0.001223	0.1145	Slope TG	−0.00083	0.001799	0.7063
FA				KFA
Slope NC	0.001208	0.000606	0.1395	Slope NC	0.002359	0.002709	0.6184
Slope TG	0.000339	0.000508	0.6747	Slope TG	0.002554	0.002322	0.5334

Fi	S	SE	P-values		S	SE	P-values

MD μm²/ms				MK
Slope NC	−0.0011	0.002073	0.7793	Slope NC	0.001712	0.002173	0.6942
Slope TG	−0.00869	0.001735	<.0001	Slope TG	0.008592	0.001818	<.0001
D_∥ μm²/ms				K _∥
Slope NC	−0.00487	0.003117	0.492	Slope NC	0.002071	0.001221	0.492
Slope TG	−0.00979	0.00261	0.0006	Slope TG	0.005322	0.001023	<.0001
D_⊥ μm²/ms				K _⊥
Slope NC	0.000724	0.002128	0.735	Slope NC	−0.00258	0.006661	0.735
Slope TG	−0.00769	0.001785	<.0001	Slope TG	0.02007	0.005584	0.001
FA				KFA
Slope NC	−0.00169	0.00129	0.5181	Slope NC	−0.0017	0.001545	0.5484
Slope TG	0.003641	0.001082	0.0015	Slope TG	0.004142	0.001295	0.0022

Fx	S	SE	P-values		S	SE	P-values

MD μm²/ms				MK
Slope NC	−0.00074	0.002606	0.9196	Slope NC	0.005345	0.003279	0.4328
Slope TG	−0.00611	0.002182	0.0181	Slope TG	0.007301	0.002743	0.0198
D_∥ μm²/ms				K _∥
Slope NC	0.00047	0.002974	0.8749	Slope NC	0.003187	0.002536	0.5693
Slope TG	−0.0087	0.002491	0.0069	Slope TG	0.00714	0.002122	0.0053
D_⊥ μm²/ms				K _⊥
Slope NC	−0.00087	0.003278	0.9196	Slope NC	0.008947	0.005019	0.4328
Slope TG	−0.0041	0.002744	0.1864	Slope TG	0.00951	0.004201	0.0433
FA				KFA
Slope NC	0.000464	0.001869	0.9196	Slope NC	−0.00086	0.002854	0.9196
Slope TG	0.000078	0.001563	0.9606	Slope TG	0.000904	0.002389	0.8073