TABLE 4.
Amino acid substitutions in the penicillin-binding domains of the PBP 1A and 2B proteins of isolates 29, 36, 89, 129, 139, and 143
| Isolate no(s) | Amino acid substitutions in:
|
|
|---|---|---|
| PBP 1A | PBP 2B | |
| 29, 36, 89 | Asp-533→Glu | None |
| Thr-574→Glu | ||
| Gln-576→Gly | ||
| Phe-577→Tyr | ||
| Leu-583→Arg | ||
| Leu-606→Ile | ||
| Val-607→Met | ||
| Asn-609→Asp | ||
| 129, 139 | Asn-443→Asp | Thr-252→Ala |
| Thr-447→Asn | Glu-282→Gly | |
| Ser-458→His | Thr-295→Ser | |
| Ile-459→Met | Glu-312→Asp | |
| Asp-473→Asn | ||
| Lys-475→Gln | ||
| Tyr-487→Phe | ||
| Thr-495→Ile | ||
| Tyr-497→His | ||
| His-503→Asn | ||
| Val-505→Ile | ||
| Asn-517→Asp | ||
| Val-518→Ala | ||
| Asp-533→Glu | ||
| 143 | Glu-388→Asp | None |
| Ser-540→Thr | ||