TABLE 4.
Amino acid substitutions in the penicillin-binding domains of the PBP 1A and 2B proteins of isolates 29, 36, 89, 129, 139, and 143
Isolate no(s) | Amino acid substitutions in:
|
|
---|---|---|
PBP 1A | PBP 2B | |
29, 36, 89 | Asp-533→Glu | None |
Thr-574→Glu | ||
Gln-576→Gly | ||
Phe-577→Tyr | ||
Leu-583→Arg | ||
Leu-606→Ile | ||
Val-607→Met | ||
Asn-609→Asp | ||
129, 139 | Asn-443→Asp | Thr-252→Ala |
Thr-447→Asn | Glu-282→Gly | |
Ser-458→His | Thr-295→Ser | |
Ile-459→Met | Glu-312→Asp | |
Asp-473→Asn | ||
Lys-475→Gln | ||
Tyr-487→Phe | ||
Thr-495→Ile | ||
Tyr-497→His | ||
His-503→Asn | ||
Val-505→Ile | ||
Asn-517→Asp | ||
Val-518→Ala | ||
Asp-533→Glu | ||
143 | Glu-388→Asp | None |
Ser-540→Thr |