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. 2021 Sep 16;9(9):e003122. doi: 10.1136/jitc-2021-003122

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Change in Ki67+PD1+CD8+ T cells throughout treatment, p=0.0004. Cycle 1 vs cycle 4 p=0.0015, cycle 1 vs cycle 6 p=0.0023. Dots at mean, error bars SD. (B) Change in CTLA-4+PD1+CD8+ T cells throughout treatment, p=0.0004. Dots at mean, error bars SD. Tukey’s multiple comparisons test showed the following significant comparisons: cycle 1 vs cycle 4 p=0.0034; cycle 1 vs cycle 6 p=0.0010; cycle 1 vs cycle 12 p=0.0336. (C) Change in CD8+CD4+ T cells throughout treatment. No significant difference was observed in the total peripheral CD8+ population after 3 cycles (p=0.81) and 5 cycles (p=0.21). Dots at mean, error bars SD.