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. Author manuscript; available in PMC: 2021 Sep 19.
Published in final edited form as: Cell Rep. 2021 Jul 27;36(4):109462. doi: 10.1016/j.celrep.2021.109462

Figure 1. ArlRS and MgrA control S. aureus skin infection severity.

Figure 1.

(A) C57BL/6 mice were infected with S. aureus through subcutaneous injection, and developing skin infection was observed. The size of dermonecrotic lesions was measured daily.

(B) On selected days, the infected areas were biopsied, and skin bacterial burden in homogenized biopsy specimens was measured.

(C and D) Additionally, skin biopsy specimens were taken on day 1 of infection, and histopathological sections of the biopsy specimens were used to measure the size of abscesses formed in skin (C) and the presence of tightly clumped staphylococcal abscess communities (SACs) inside these abscesses (D).

Scale bars, 300 μm. Data are shown as mean ± SEM. N = 9 (A), 5–8 (B), and 8 (C and D). *p < 0.05; **p < 0.01; ***p < 0.001. All p values are for comparisons to WT.