Table 2. Clinicopathological parameters of NDRG1 and DNMTsmRNA expression from TCGA cohort.
| Variable | Patients (n) |
NDRG1 Low (High) |
p | DNMT1 Low (High) |
p | DNMT3A Low (High) |
p | DNMT3B Low (High) |
p |
|---|---|---|---|---|---|---|---|---|---|
| Gender | |||||||||
| Female | 120 | 61 (59) | 0.908 | 56 (64) | 0.355 | 56 (64) | 0.355 | 61 (59) | 0.817 |
| Male | 195 | 97 (98) | 102 (93) | 102 (93) | 96 (99) | ||||
| Age | |||||||||
| ＜60 | 100 | 52 (48) | 0.717 | 47 (53) | 0.469 | 50 (50) | 1.000 | 49 (51) | 0.904 |
| ≥60 | 215 | 106 (109) | 111 (104) | 108 (107) | 108 (107) | ||||
| Stage | |||||||||
| I | 42 | 18 (24) | 0.297 | 23 (19) | 0.881 | 26 (16) | 0.190 | 20 (22) | 0.814 |
| II | 101 | 47 (54) | 51 (50) | 51 (50) | 49 (52) | ||||
| III | 139 | 78 (61) | 69 (70) | 62 (77) | 69 (70) | ||||
| IV | 33 | 15 (18) | 15 (18) | 19 (14) | 19 (14) | ||||
| Invasion depth | |||||||||
| T1 | 15 | 9 (6) | 0.023* | 12 (3) | 0.049* | 11 (4) | 0.090 | 9 (6) | 0.216 |
| T2 | 63 | 21 (42) | 33 (30) | 37 (26) | 28 (35) | ||||
| T3 | 151 | 84 (67) | 77 (74) | 69 (82) | 70 (81) | ||||
| T4 | 66 | 44 (42) | 36 (50) | 41 (45) | 50 (36) | ||||
| Lymph node metastasis (N) | |||||||||
| N0 | 99 | 46 (53) | 0.348 | 49 (50) | 0.828 | 52 (47) | 0.864 | 50 (49) | 0.206 |
| N1 | 83 | 48 (35) | 40 (43) | 43 (40) | 44 (39) | ||||
| N2 | 69 | 31 (38) | 38 (31) | 33 (36) | 27 (42) | ||||
| N3 | 64 | 33 (31) | 31 (33) | 30 (34) | 36 (28) | ||||
| Distant metastasis | |||||||||
| No | 295 | 149 (146) | 0.652 | 149 (146) | 0.652 | 145 (150) | 0.248 | 144 (151) | 0.174 |
| Yes | 20 | 9 (11) | 9 (11) | 13 (7) | 13 (7) | ||||
| Differentiation | |||||||||
| G1 | 7 | 3 (4) | 0.293 | 4 (3) | 0.906 | 3 (4) | 0.758 | 3 (4) | 0.030* |
| G2 | 108 | 48 (60) | 55 (53) | 57 (51) | 43 (65) | ||||
| G3 | 200 | 107 (93) | 99 (101) | 98 (102) | 111 (89) |
Note:
*
p < 0.05.