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. 2021 Aug 17;49(16):9097–9116. doi: 10.1093/nar/gkab682

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — sCMRs were linked to sex hormone biology. (A) sCMR were enriched for sites whose DNAm levels are linked to sex hormone levels. Significance was based on a Fisher exact test q value < 0.05 following Benjamini–Hochberg multiple test correction. (B) Eleven sCMRs showed significant changes in DNAm levels in HTB-22 breast cancer cells based on estradiol treatment. (C) UMAP of breast cancer tissue samples showed a strong separation based on estrogen and progesterone receptor status when the sCMR composite beta values for the 148 sCMRs present in the dataset (left) were used. This effect was largely driven by three sCMRs (right)