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MsPA modulates protein-binding profile of gapmer ASOs. (A) Competition binding constants of MsPA ASOs for model PS ASO binding proteins, PC4, SSBP and RNaseH1 using a NanoBret assay. (B) Dose response curves showing that MsPA in the DNA gap has a bigger effect on protein binding than MsPA in the cEt wings. Blue letters indicate cEt, black DNA, red—2′-O-Me, subscript pink m = MsPA, s = PS, superscript m = 5-Me group on cytosine nucleobases.
