Figure 5.

Simulated conformations of a holocentric-like chromosome with 100 centromeric nucleosomes with anchoring effect after condensation by 1000 LEs (see Supplementary Movie S3 for the entire simulation). Centromeric nucleosomes are colored from blue to red according to the position in the linear genome. Left bar represents the chromosome length and colored lines indicate the position of centromeric nucleosomes. (A) The decondensed conformation represents an interphase with dispersed centromeric nucleosomes. (B) Condensation of a chromosome due to loop extrusion. Centromeric nucleosomes are aligned in the axis of the chromosome following the position in the chromosomal sequence. (C) Condensed holocentric chromosome colored from blue to red, as indicated by the bar at the right. The chromosome is entirely linearly arranged along the chromosome axis, following the position in the chromosomal sequence.