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. 2021 Aug 5;49(16):9053–9065. doi: 10.1093/nar/gkab648

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Comparison between simulated (A) holocentric- and (B) monocentric-like chromosomes at different stages of the condensation process (Supplementary Videos S3 and 4). Bars indicate chromosome length and red lines the position of the centromeric nucleosomes. (A) The condensed holocentric-like chromosome presents an average loop size of 325 nucleosomes and a chromosome length of 374 nucleosomes. (B) The condensed monocentric-like chromosome presents loop sizes of 59 and 260 nucleosomes inside and outside the centromeric region, respectively, and a chromosome length of 650 nucleosomes. The inset shows the centromeric region, with smaller chromatin loops, resembling the centromere constriction of monocentric chromosomes.