Figure 7.

Simulation of a groove-like centromere along a holocentric condensed chromosome. (A) Representation of a simulated kinetochore arrangement as a rectangular bar formed by fixed spheres (in lilac). Red spheres represent the line of centromeric nucleosomes. Pairs of yellow spheres represent nucleosomes bound by LEs, and the chromatin fibre is shown as white beads on a string. (B) Final conformation of a simulated holocentric chromosome in the presence of the kinetochore arrangement. Components follow the same code color as in (A). The kinetochore is embedded in the chromatin fibre. On the right, the kinetochore is not shown so that the centromeric line is visible at the bottom of the groove and surrounded by LEs. Transversal (C) and longitudinal (D) cross-sections evidence the centromeric groove-like structure.