Table 2.

List of parameters and default values of computational model

Parameter	Description	Value	References
$a_1$	Integrin catch–slip bond parameter	2.2	To fit data of Kong et al. (2009)
$b_1$	Integrin catch–slip bond parameter	29.9	To fit data of Kong et al. (2009)
$c_1$	Integrin catchslip bond parameter	8.4	To fit data of Kong et al. (2009)
$a_2$	Integrin catch–slip bond parameter	1.2	To fit data of Kong et al. (2009)
$b_2$	Integrin catch–slip bond parameter	16.2	To fit data of Kong et al. (2009)
$c_3$	Integrin catch–slip bond parameter	37.8	To fit data of Kong et al. (2009)
R	Cell radius	12 μm	Typical value
$\mathrm{\Delta }R$	Linking range around cell	±3 μm	–
$D_f$	Diameter of collagen fibers	180 nm	Van Der Rijt et al. (2006)
$E_f$	Young’s modulus of collagen fibers	1.1 MPa	Jansen et al. (2018)
$\dot{c}$	Contraction rate of stress fibers	$0.1\frac{\mu \text{m}}{\text{s}}$	Choquet et al. (1997); Moore et al. (2010)
$k_{B}T$	Thermal energy	$4.28·{10}^{-3}\mathrm{aJ}$	at 37${}^{\circ }\text{C}$
$L_i$	RVE edge length in i-th coordinate direction	$245\mu m$	–
$k_{\mathit{on}}^{f-f}$	Chemical association rate for fiber linker	$0.0001s^{-1}$	–
$k_{\mathit{off}}^{f-f}$	Chemical dissociation rate for fiber linker	$0.0001{\mathrm{s}}^{-1}$	–
$\mathrm{\Delta }x$	Bell parameter	0.5 nm	–
$N_{FA,max}$	Maximal number of focal adhesions per cell	65	Kim and Wirtz (2013); Horzum et al. (2014); Mason et al. (2019)
$N_{i,FA,max}$	Maximal number of integrins per focal adhesion	1000	Wiseman (2004); Elosegui-Artola et al. (2014)
$N_{i,ic,max}$	Maximal number of integrins per cluster	20	Changede et al. (2015); Cheng et al. (2020)
$k_{\mathit{on}}^{c-f}$	Chemical association rate for integrin	$0.1s^{-1}$	slightly modified Zhu et al. (2016)
$d^{i-f}$	Distance between binding spots for integrinfiber links	50 nm	López-García et al. (2010)