Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Compounds arising from tripeptide modification and their predicted pocket occupancies.
| Tripeptide for modification50 | Potent compounds | IC50 (µM) | |
| Cap-Arg-Lys-Phg-NH2 | Compound 3 | IC50 = 0.21 µM | |
| Compound 9 | IC50 = 0.018 µM | ||
| Compound 12 | IC50 = 0.46 ± 0.02 µM | ||
| Residues of inhibitor | Predicted pocket occupancies | ||
| Compound 3* | Compound 9# | Compound 12 | |
| Phg/Phg modification# | S1′ | S1 | S1 |
| Arg/Arg-mimetic* | S2 | S2 | S2 |
| Lys | S1 | S1, S3, S4 | S1, S2 |
| Cap group (varying) | S3 | S3, S4 | S3, S4 |
