. 2021 Sep 20;49:116415. doi: 10.1016/j.bmc.2021.116415

Table 8.

Result of antiviral activity of previously reported inhibitors, Chu et al. (2015).

Sl. No.	Structure	Supplied by	% purity	Ki/EC₅₀/IC₅₀ (Reported)	Cellular toxicity	Antiviral activity	Reason for no antiviral activity	Permeability (P) (10^-6 cmS^-¹)
1	Ac-RTSKKR-CONH₂	GL Biochem (China)	>95%	Ki = 12.14 µM	X	X	Inability to permeate & disadvantage of Peptide nature of the drug	0 Not detectible
2		Maybridge (UK)	>95%	Ki = 44 ± 5 µM	X	X	Positive charge on guanidine and basic moiety limitations	0 Not detectible
3	BZ-Ala-Lys-Arg-Arg-H	Mimotopes (Australia)	62%	Ki = 5.3 µM	X	X	Very high charge On compound	0 Not detectible
4		Otava (Ukraine)	>95%	Ki = 17.0 ± 4.3 µM IC₅₀ = 67.0 ± 7 µM	X	X	High IC₅₀ value	4.12 ± 0.45
5	*ARDP0006*	Sigma-Aldrich (USA)	>95%	*EC₅₀ = 4.2 ± 1.9* µM	X		Highly permeable	*4.45 ± 0.6*
6		In-house	>95%	Ki = 2.0 µM	X	X	Poor permeability owing to high polarity	0 Not detectible
7		Cambridge Screening Library (USA)	>95%	NR	X	X	Lacked membrane permeability	0 Not detectible
8		Maybridge (UK)	>95%	Ki = 35.7 µM	X	X	Unknown reason	8.40 ± 0.15
9		Cambridge Screening Library (USA)	>95%	Ki = 15 ± 3 µM	X	X	Lacked membrane permeability	0 Not detectible
10		Cambridge Screening Library (USA)	>95%	IC₅₀ = 27.0 ± 1.3 µM	X	X	Positively charged nature of compound	0 Not detectible
11		GL Biochem (China)	>95%	Ki = 15.6 ± 1.1 µM	X	X	Highly cationic nature of compound	0 Not detectible
12		GL Biochem (China)	>95%	Ki = 1.4 ± 0.1 µM	X	X	Highly cationic nature of compound	0 Not detectible
13	Alexidine hydrochloride	Sigma-Aldrich (USA)	>95%	Ki = 41 ± 3 µM	X	X	Cationic guanidine moieties	0 Not detectible
14	Ivermectin	Sigma-Aldrich (USA)	>95%	Ki = 79 ± 21 µM		---	---	---
15	Selamectin	Sigma-Aldrich (USA)	>95%	Ki = 63 ± 18 µM		‘ ---	---	---