Fig. 6.
The tumor cell MMP3 may facilitate tumor invasion in the mouse colon cancer model. (A) Each mouse in group (n = 6) was injected with 3 × 106 MC-38-Shmmp3 or MC-38-Vector cells through tail vein for generating metastatic model. The mouse lungs (1-6# in MC-38-Shmmp3 group,7-12# in MC-38-Vector group) were dissected to observe the lung tumor metastasis 20 days post-injection, and the arrow indicates the lung tumor formations. Right panel was the lesion number of each mouse lung. (B) The mouse lungs in each group were stained with HE, and the representive pathological sections of the lung tumors were labed with red rectangles (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).