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. 2021 Aug 11;62:100105. doi: 10.1016/j.jlr.2021.100105

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 1 — QTL analysis and Lepr^L536Hfs*⁶ mutation. A: Pictures of 12-week-old female mice on mm scale. B: Quantitative trait locus (QTL) identification on chromosome 4 with R/qtl using Haley Knott regression (37). C: Nucleotide and amino acid sequences of the QTL region on chromosome 4 resulted in the identification of the point mutation at position 536 causing the novel Lepr^L536Hfs*⁶ spontaneous Lepr mutant mice. The mutation results in a deletion in exon 11 which leads to a frame shift and stop codon within the next 5 aa. D: Exemplary sequence of a wt, a heterozygous Lepr^L536Hfs*^6/wt, and a homozygous Lepr^L536Hfs*⁶ mouse. F: Schematic representation of the Lepr protein with highlighted positions for Lepr^L536Hfs*⁶ and Lepr^db/db mutations as well as cytokine receptor homology (CRH1/2), Immunoglobulin domain (Ig), fibronectin III domain (FNIII).