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. 2021 Sep 15;14:4015–4030. doi: 10.2147/DMSO.S326054

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© 2021 Sun et al.

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The mechanism of diosgenin on lipid metabolism. As Figure 1 shows, the paper will elaborate the lipid metabolism regulating mechanism of diosgenin in detail. It includes diosgenin’s effects on inhibiting intestinal absorption of lipids, regulation of cholesterol transport, promoting cholesterol conversion into bile acid and excretion, inhibiting the endogenous lipid biosynthesis, effect on antioxidation, regulating lipoprotein lipase activity, and regulating transcription factors related to lipid metabolism.