Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 20;12:5423. doi: 10.1038/s41467-021-25430-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Arm-wide chromosomal gain (left) and loss (right) were analyzed across 112 HB genomes using GISTIC 2.0. b Epicenter mapping of recurrent homozygous deletions in the vicinity of IRF2 gene detected in 3 HB cases. c Epicenter mapping of focal LOH and UPD in chromosome 11p spanning H19, IGF2, ASCL2, and KCNQ1 genes. d, A total of 112 HB tumors are hierarchically clustered into two groups based on arm-level somatic copy number alterations (SCNAs) defined by GISTIC 2.0; CIN (chromosomal instability, n = 32) and GS (genomically stable, n = 80). The heat map shows copy number statuses in each tumor (horizontal axis) plotted by chromosomal location (vertical axis) in the top panel. The middle panel represents the status of focal copy number (CN) changes in chromosomes 2q and 4p, LOH or UPD in chromosome 11p, and the driver mutations (CTNNB1, TERT). The bottom of the panel shows clinical and pathological parameters of HB patients. Statistical significance was analyzed by Fisher’s exact test (*p < 0.01).