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. 2021 Sep 20;12:5423. doi: 10.1038/s41467-021-25430-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Methylation statuses of the IGF2 promoters across 146 HB and 13 normal livers. The top panel represents chromatin statuses of human embryonic stem cells (H9, E003), their vitro derivative cells toward endoderm lineage (E011), fetal colon (E084), adult colon (E106), and adult liver tissues (E066), as defined in the Roadmap Epigenomics project (https://egg2.wustl.edu/roadmap/web_portal/index.html) around the IGF2 gene (chr11:2,140,000-2,195,000). 1_TssA (Red), Active TSS; 2_TssAFlnk (Orange Red), Flanking Active TSS; 3_TxFlnk (LimeGreen), Transcr. at gene 5’ and 3’; 4_Tx (Green), Strong transcription; 5_TxWk (DarkGreen), Weak transcription; 6_EnhG (GreenYellow), Genic enhancers; 7_Enh (Yellow), Enhancers; 8_ZNF/Rpts (Medium Aquamarine), ZNF genes & repeats; 9_Het (Pale Turquoise), Heterochromatin; 10_TssBiv (IndianRed), Bivalent/Poised TSS; 11_BivFlnk (DarlSalmon), Flanking Bivalent TSS/Enh; 12_EnhBiv (DarkKhaki), Bivalent Enhancer; 13_ReprPC (Silver), Repressed PolyComb; 14_ReprPCWk (Gainsboro), Weak Repressed PolyComb; 15_Quies (White), Quiescent/Low. Red triangles represent the transcription start sites of five IGF2 promoters. The heat map in the bottom panel shows methylation statuses of each tumor (vertical axis) plotted in order of the physical position along with the alternative promoters (horizontal axis). The left panel shows the age at diagnosis, aberration pattern (UPD, LOH, ROH and LOI) and the expression level of IGF2 in each case.