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. 2021 Sep 20;12:5423. doi: 10.1038/s41467-021-25430-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Unsupervised clustering of 146 childhood hepatoblastoma (HB) and 11 non-cancerous livers using the most variably methylated CpGs located at the enhancer regions of adult and fetal livers. The heat map shows the methylation level of each tumor (horizontal axis) plotted by the probe sets (vertical axis) in the top panel. The bottom panel shows clinical and pathological parameters, molecularly defined subtypes of HB patients. Statistical significance was analyzed using Fisher’s exact test (*p < 0.01). b Significant motifs of transcription factors most strongly enriched in the subtype-specific hyper/hypomethylated probe sets using the TRAP (Transcription factor Affinity Prediction Web Tools). The matrix entries have an identifier that indicates one of the six groups of biological species (V$ vertebrates, I$ insects, P$ plants, F$ fungi, N$ nematodes, B$ bacteria). The P-value for each sequence was combined using the two-sided Fisher’s method and corrected for multiple testing.