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. 2021 Sep 20;93:28–34. doi: 10.1016/j.ejim.2021.09.007

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© 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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Fig 2 — Pre-existing ACE2 deficiency (as documented for elderly patients, diabetes mellitus, COPD, hypertension, and chronic disease) contributes to an unfavourable outcome in SARS-CoV-2 infection. See text for details. Legend: A_II=angiotensin II; A_1,7=angiotensin_1,7; ACE2=angiotensin coverting enzyme 2; RAAS=renin-angiotensin-aldosterone system; SARS-CoV-2= severe acute respiratory syndrome coronavirus-2.