TABLE 3.
Polymorphisms of DILI-related transporter genes identified in GWAS and CGS.
| Genes | Drug | Method | Cohort | OR | P | 95%Cl |
|---|---|---|---|---|---|---|
| ABCB1 rs1045642 (3435C→T) | Nevirapine | CGS | 9 cases, 49 P (American) Ritchie et al. (2006) | 0.254 | 0.021 | 0.09–0.76 |
| ABCB1 rs2032582 | Nevirapine | 30 cases, 414 P (Japanese) Fukunaga et al. (2016) | 2.59 | 6.8 × 10−4 | 1.49–4.56 | |
| ABCC2 rs717620 (24C→T) | Diclofenac | 24 cases, 48 T, 112 P (English) Daly et al. (2007) | C vs. PC: 6.3 | C vs. PC: 2*10−4 | C vs. PC: 2.38–16.7 | |
| C vs. T: 5.0 | C vs. T: 0.005 | C vs. T: 1.71–14.7 | ||||
| SLCO1B1 rs4149056 | HD-MTX | 105 cases Yang et al. (2017) | U | 0.025 | U | |
| SLCO1B1*1a (388A/521T) | Methimazole | 44 cases, 118 P (Chinese) Jin et al. (2019) | 2.21 | 0.023 | 1.11–4.39 | |
| SLCO1B1*1b (388G/521T) | Methimazole | 44 cases, 118 P (Chinese) Jin et al. (2019) | 0.52 | 0.028 | 0.29–0.93 | |
| SLCO1B1*15 | Rifampicin | 118 cases, 155 P (Chinese) Li et al. (2012) | 2.04 | 0.03 | 1.05–3.96 | |
| SLCO1B1*15 | Bosentan | 9 cases, 14 P Roustit et al. (2014) | U | 0.66 | U |
OR, odds ratio; P, p value; 95%CI, 95% confidence interval; C, medication with adverse reactions; T, medication with no adverse reactions; PC, population control; U, unknown.