Table 1.
Characteristics of 245 COVID-19 patients within 3 days of admission.
| Characteristics | b.Normal group | b.LLCHN group | p value |
|---|---|---|---|
| Number (%) | 146 (59.6%) | 99 (40.4%) | |
| Age | 33.0 (26.0–43.8) | 39.0 (32.5–51.0) | <0.001 |
| Female | 49 (33.6%) | 46 (46.5%) | 0.042 |
| BMI | 22.9 (20.5–25.7) | 22.4 (20.1–24.8) | 0.258 |
| SBP | 129.0 (117.0–138.0) | 130.0 (116.0–140.0) | 0.354 |
| Smoking | 29 (20.0%) | 9 (9.1%) | 0.021 |
| Alcohol | 43 (29.5%) | 22 (22.2%) | 0.208 |
| Highest temperature | 37.0 (36.5–37.5) | 37.0 (36.8–37.8) | 0.075 |
| Chest congestion | 3 (2.1%) | 8 (8.1%) | 0.026 |
| Liver cirrhosis | 1 (0.7%) | 0 (0.0%) | 0.409 |
| HBV | 8 (5.5%) | 4 (4.0%) | 0.600 |
| Clinical classification | 0.001 | ||
| Asymptomatic | 54 (37.0%) | 24 (24.2%) | |
| Mild | 26 (17.8%) | 10 (10.1%) | |
| Moderate | 65 (44.5%) | 57 (57.6%) | |
| Severe | 1 (0.7%) | 8 (8.1%) | |
| Inflammatory indicators | |||
| WBC (×109/L) | 5.9 (4.8–7.1) | 7.0 (5.8–8.5) | <0.001 |
| RCP (mg/L) | 5.0 (1.0–10.0) | 6.0 (2.0–28.5) | 0.082 |
| SAA (mg/L) | 18.0 (5.0–88.0) | 51.0 (11.5–137.0) | 0.006 |
| Lymphocyte ratio (%) | 34.5 (29.5–39.9) | 20.3 (16.8–22.8) | <0.001 |
| Neutrophil ratio (%) | 57.7 (51.6–63.3) | 73.0 (67.7–78.5) | <0.001 |
| Liver biochemical indicators | |||
| ALT (U/L) | 20.0 (13.0–32.0) | 19.0 (12.5–39.0) | 0.882 |
| AST (U/L) | 22.0 (18.0–27.0) | 24.0 (17.0–29.5) | 0.566 |
| GGT (U/L) | 23.0 (16.0–35.0) | 22.0 (15.5–36.5) | 0.846 |
| TBIL (µmol/L) | 12.8 (9.5–18.3) | 14.5 (9.6–19.8) | 0.393 |
| ALP (U/L) | 77.0 (62.0–90.0) | 75.0 (63.0–89.5) | 0.799 |
| APTT (s) | 28.0 (26.6–30.0) | 27.9 (26.6–31.4) | 0.488 |
| Others | |||
| GFR (mL/min) | 116.0 (103.0–127.0) | 112.0 (100.2–128.5) | 0.397 |
| LppA (mg/L) | 110.8 (64.2–324.9) | 155.2 (76.8–298.2) | 0.200 |
| Hb (g/L) | 148.0 (134.0–156.0) | 140.0 (130.0–152.0) | 0.015 |
| Sodium concentration (mmol/L) | 138.7 (137.6–140.1) | 138.4 (136.3–139.8) | 0.102 |
| ABE (mmol/L) | 0.7 (-0.5–1.7) | 0.4 (-0.7–1.8) | 0.785 |
| AG (mmol/L) | 10.0 (9.0–13.1) | 10.7 (8.9–12.9) | 0.561 |
Data are n (%) or median (IQR) unless otherwise indicated. Participants with the peak values of lymphocyte ratio ≤26.1 and neutrophil ratio ≥62.0 within 3 days of admission were classified as b.LLCHN group, and others were classified as b.Normal group.
BMI, body mass index; HBV, hepatitis B Virus; WBC, white blood cell count; RCP, rapid C-reactive protein; SAA, serum amyloid A protein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl transferase; TBIL, total bilirubin; ALP, alkaline phosphatase; APTT, activated partial thromboplastin time; GFR, glomerular filtration rate; LppA, lipoprotein A; Hb, hemoglobin; ABE, actual base excess; AG, anion gap; b.LLCHN, low lymphocyte ratio complicated with high neutrophil ratio at baseline.