Table 2.

Lateral relations of LLCNH to the incidence of liver dysfunction events in the COX model.

	Unadjusted	Adjusted I	Adjusted II
	HR (95% CI)	HR (95% CI)	HR (95% CI)
Mild liver dysfunction	No. M = 1409	No. M = 1409	No. M = 1409
	1.44 (1.12, 1.84)*	1.56 (1.20, 2.03)*	1.36 (1.01, 1.82)*
Moderate liver dysfunction	No. M = 1382	No. M = 1382	No. M = 1382
	1.50 (1.16, 1.96)*	1.63 (1.24, 2.16)*	1.37 (1.01, 1.85)*
Severe liver dysfunction	No. M = 1239	No. M = 1239	No. M = 1239
	1.37 (0.89, 2.12)	1.60 (1.01, 2.54)*	1.72 (1.02, 2.90)*

Unadjusted: unadjusted for any covariables.

Adjusted I: adjusted for age, sex, and body mass index (BMI) on admission.

Adjusted II: adjusted for fixed covariates including age, sex, body mass index (BMI), SBP, smoking, alcohol, highest temperature, chest congestion, liver cirrhosis, HBV, and clinical classification on admission, and time-varied covariates including white blood cell count (WBC), rapid C-reactive protein (RCP), serum amyloid A protein (SAA), alkaline phosphatase (ALP), activated partial thromboplastin time (APTT), glomerular filtration rate (GFR), lipoprotein A (LppA), hemoglobin (Hb), sodium concentration, actual base excess (ABE), and anion gap (AG) during the lateral observation period.

LLCNH, low lymphocyte ratio complicated with high neutrophil ratio (lymphocyte ratio ≤26.1 and neutrophil ratio ≥62.0); HR, hazard ratio; CI, confidence interval; No. M, the number of measurements.

^*The incidence of liver dysfunction in the LLCHN group was significantly different compared to the normal group.