Table 3.

Lateral associations of the incidence of liver dysfunction events with per-SD increment in lymphocyte ratio or neutrophil ratio in the LLCHN group.

	Unadjusted	Adjusted I	Adjusted II
	HR (95% CI)	HR (95% CI)	HR (95% CI)
Mild liver dysfunction	No. M = 612	No. M = 612	No. M = 612
LR (per-SD increment)	0.55 (0.39, 0.77)*	0.51 (0.35, 0.73)*	0.58 (0.39, 0.85)*
NR (per-SD increment)	1.44 (1.00, 2.06)*	1.57 (1.08, 2.27)*	1.26 (0.84, 1.88)
Moderate liver dysfunction	No. M = 603	No. M = 603	No. M = 603
LR (per-SD increment)	0.53 (0.37, 0.77)*	0.49 (0.34, 0.71)*	0.56 (0.38, 0.83)*
NR (per-SD increment)	1.42 (0.97, 2.07)	1.55 (1.05, 2.29)*	1.32 (0.87, 2.01)
Severe liver dysfunction	No. M = 534	No. M = 534	No. M = 534
LR (per-SD increment)	0.50 (0.27, 0.92)*	0.44 (0.23, 0.84)*	0.37 (0.18, 0.77)*
NR (per-SD increment)	1.66 (0.85, 3.24)	1.74 (0.85, 3.54)	1.99 (0.90, 4.41)

Unadjusted: unadjusted for any covariables.

Adjusted I: adjusted for age, sex, and body mass index (BMI) on admission.

Adjusted II: adjusted for fixed covariates including age, sex, body mass index (BMI), SBP, smoking, alcohol, highest temperature, chest congestion, liver cirrhosis, HBV, and clinical classification on admission, and time-varied covariates including white blood cell count (WBC), rapid C-reactive protein (RCP), serum amyloid A protein (SAA), alkaline phosphatase (ALP), activated partial thromboplastin time (APTT), glomerular filtration rate (GFR), lipoprotein A (LppA), hemoglobin (Hb), sodium concentration, actual base excess (ABE), and anion gap (AG) during the lateral observation period.

LLCNH, low lymphocyte ratio complicated with high neutrophil ratio (lymphocyte ratio ≤26.1 and neutrophil ratio ≥62.0); HR, hazard ratio; CI, confidence interval; No. M, the number of measurements.

^*A result that was considered statistically significant.