Table 4.
Longitudinal threshold effect analyses for the relations between b.LLCHN and the incidence of 3-, 6-, and 9-day liver dysfunction.
| 3 days after admission | 6 days after admission | 9 days after admission | ||||
|---|---|---|---|---|---|---|
| AST <35 U/L | AST ≥35 U/L | AST <35 U/L | AST ≥35 U/L | AST <35 U/L | AST ≥35 U/L | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Mild liver dysfunction | ||||||
| Unadjusted | 1.12 (0.78, 1.59) | 2.13 (1.27, 3.58)* | 1.08 (0.75, 1.53) | 1.85 (1.09, 3.15)* | 1.13 (0.77, 1.64) | 1.48 (0.85, 2.59) |
| Adjusted I | 1.24 (0.86, 1.80) | 3.14 (1.73, 5.69)* | 1.19 (0.82, 1.73) | 2.75 (1.48, 5.09)* | 1.32 (0.88, 1.97) | 2.44 (1.25, 4.75)* |
| Adjusted II | 1.11 (0.71, 1.73) | 8.85 (2.70, 28.99)* | 1.14 (0.69, 1.86) | 7.88 (2.30, 27.03)* | 1.22 (0.75, 1.99) | 5.97 (1.51, 23.67)* |
| Moderate liver dysfunction | ||||||
| Unadjusted | 1.13 (0.78, 1.64) | 2.13 (1.27, 3.58)* | 1.11 (0.76, 1.61) | 1.85 (1.09, 3.15)* | 1.14 (0.77, 1.68) | 1.48 (0.85, 2.59) |
| Adjusted I | 1.33 (0.90, 1.98) | 3.14 (1.73, 5.69)* | 1.31 (0.88, 1.94) | 2.75 (1.48, 5.09)* | 1.37 (0.90, 2.07) | 2.44 (1.25, 4.75)* |
| Adjusted II | 1.21 (0.75, 1.95) | 8.85 (2.70, 28.99)* | 1.34 (0.78, 2.29) | 7.88 (2.30, 27.03)* | 1.26 (0.76, 2.09) | 5.97 (1.51, 23.67)* |
| Severe liver dysfunction | ||||||
| Unadjusted | 0.90 (0.46, 1.79) | 2.86 (1.32, 6.17)* | 0.90 (0.46, 1.79) | 2.67 (1.23, 5.81)* | 0.99 (0.49, 1.98) | 2.06 (0.90, 4.74) |
| Adjusted I | 1.06 (0.52, 2.17) | 3.83 (1.63, 9.02)* | 1.06 (0.52, 2.17) | 3.50 (1.46, 8.40)* | 1.16 (0.56, 2.41) | 3.53 (1.34, 9.29)* |
| Adjusted II | 1.30 (0.47, 3.63) | 6.73 (0.96, 47.34) | 1.78 (0.57, 5.50) | 6.45 (0.89, 46.95) | 1.30 (0.45, 3.73) | 3.74 (0.23, 60.25) |
Unadjusted: unadjusted for any covariables.
Adjusted I: adjusted for age, sex, and body mass index (BMI) at baseline.
Adjusted II: adjusted for age, sex, body mass index (BMI), SBP, smoking, alcohol, highest temperature, chest congestion, liver cirrhosis, HBV, clinical classification, white blood cell count (WBC), rapid C-reactive protein (RCP), serum amyloid A protein (SAA), alkaline phosphatase (ALP), activated partial thromboplastin time (APTT), glomerular filtration rate (GFR), lipoprotein A (LppA), hemoglobin (Hb), sodium concentration, actual base excess (ABE), and anion gap (AG) at baseline.
b.LLCNH, low lymphocyte ratio complicated with high neutrophil ratio at baseline (baseline lymphocyte ratio ≤26.1 and neutrophil ratio ≥62.0); HR, hazard ratio; CI, confidence interval.
*The incidence of liver dysfunction in the b.LLCHN group was significantly different compared to the b.normal group.