FIGURE 2.

Modification of sHDL particles can facilitate brain, vascular cell, and macrophage delivery. HDL-like NPs labeled with phospholipid-containing dyes such as rhodamine and probes conjugated with CS-6253, an ABCA1 agonist, can target ABCA1 on endothelial cells and macrophages to deliver cargo. Incorporation of MRI contrast agents such as gadolinium into HDL can increase signal. In SR-BI positive cells, sHDLs comprised of apoA-I can bind SR-BI and are taken up by the cell where cargo is delivered. ABCA1, ATP Binding Cassette Subfamily A Member 1; SR-BI, Scavenger receptor, class B type 1.