Table 3.
RLC Metabolic Stability Curve Parameters
| Time (min) | Meana (ng/mL) | SD | Xa | LN Xa | Analytical Parameters |
|---|---|---|---|---|---|
| 0 | 475.56 | 4.03 | 100 | 4.61 | Regression equation: Y = −0.02015*Xb + 4.470 |
| 2.5 | 391.62 | 2.52 | 82.35 | 4.41 | |
| 5 | 358.81 | 1.98 | 75.45 | 4.32 | r2: 0.9390 |
| 10 | 316.58 | 5.06 | 66.57 | 4.20 | |
| 15 | 292.66 | 3.63 | 61.54 | 4.12 | Slope: −0.02015 |
| 20 | 275.06 | 5.41 | 57.84 | 4.06 | |
| 40 | 194.31 | 5.65 | 40.86 | 3.71 | t1/2: 34.39 min and |
| 50 | 180.24 | 4.98 | 37.9 | 3.63 | Clint: 20.15 µL/min/mg |
| 70 | 160.98 | 3.56 | 33.85 | 3.52 | |
| 90 | 141.10 | 2.97 | 29.67 | 3.39 | |
| 120 | 122.17 | 3.87 | 25.69 | 3.25 |
Notes:aAverage of three repeats. bX: Average of the percentage remaining of RLC for the three repeats. Linear range is indicated by bold font.