FIGURE 2.

Comparison of erythropoietic and non-erythropoietic receptor signaling. (A) Erythropoietic signaling induced by EPO binding to EPOR dimer and causing Jak2 driven phosphorylation of STAT. (B) Non-erythropoietic signaling induced by binding of non-erythropoietic EPO-mimetic molecules such as CEPO, ARA 290 and NL 100. Non-erythropoietic molecules bind to either an EPOR-bCR heteroreceptor or cause the EPOR dimers to depart from the 120° angular orientation that supports erythropoiesis. Jak 2–Janus kinase 2, STAT - Signal transducer and activator of transcription, EPOR–erythropoietin receptor, bCR–betacommon receptor, CREB–cAMP response element binding protein, CBP–CREB binding protein and BDNF–Brain derived neurotrophic factor.