FIGURE 4.

Characterization of the impact of hypobaric and normobaric hypoxia on skeletal muscle angio-adaptive responses. Original research studies cited in the review and analyzing capillary density (CD), capillary-to-fiber ratio (C/F), and expression levels of angio-adaptive molecules in skeletal muscle tissue in response to ambient hypoxia exposure were characterized based on the nature of their hypoxic environment: Hypobaric or normobaric. Studies reporting significant changes in capillarization (CD or C/F), in molecular expression, or in both (“Overall”) are highlighted in color. Studies involving a physical activity component are identified by an asterisk. The mouse and human silhouette symbols distinguish studies conducted in animal models or human subjects.