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. 2021 Sep 6;12:738473. doi: 10.3389/fimmu.2021.738473

Figure 5.

Figure 5

TRIM21 exposure at the cell surface may occur due to apoptosis. In foetal CHB, cross-reactive maternal autoantibodies may bind to and block L-type calcium channels leading to arrhythmia and cardiomyocyte apoptosis. This releases intracellular antigens such as TRIM21 for antigen presentation, driving subsequent autoimmunity.