FIGURE 6.

8-MOP relieved the inflammatory and oxidative stress responses in articular cartilage. The Wistar rat OA model was established by intraarticular injection of 4% papain. Rats were divided into four groups: The sham group, the 8-MOP (30 μmol/kg, i.p.) group, the OA group, and the OA + 8-MOP (30 μmol/kg, i.p.) group. (A–F). The levels of inflammatory cytokines (IL-6, TNF-α, and IL-18) were detected by qRT-PCR and ELISA. (G–I): The oxidative stress factors (MDA, SOD, and GSH-PX) in the OA site were measured by the MDA, SOD, and GSH-PX detection kits. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001. (n = 5).