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. 2021 Sep 6;9:710558. doi: 10.3389/fcell.2021.710558

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Copyright © 2021 Gu, Gu, Wang, Yao and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune landscape of uveal melanoma (UM). (A) Unsupervised clustering was applied to 79 UM patients from the The Cancer Genome Atlas (TCGA) database using the single-sample gene-set enrichment analysis (ssGSEA) scores of 24 immune cell types. Mutation status of G protein subunit alpha q (GNAQ), G protein subunit alpha 11 (GNA11), splicing factor 3b subunit 1 (SF3B1), and BRCA1-associated protein 1 (BAP1), sex, survival, and stage are annotated in the lower panel. (B) Kaplan–Meier curves for the overall survival (OS) of UM patients in the TCGA dataset grouped by high and low infiltration levels. (C) Unsupervised clustering was applied to 57 UM patients from the GSE44295 dataset using the ssGSEA scores of 24 immune cell types. Metastatic status, sex, and survival are annotated in the lower panel. (D) Kaplan–Meier curves for the OS of UM patients in the GSE44295 dataset grouped by high and low infiltration levels.